Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer.
Identifieur interne : 001117 ( Main/Exploration ); précédent : 001116; suivant : 001118Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer.
Auteurs : Rebekah L. Zinn [États-Unis] ; Eric E. Gardner ; Irina Dobromilskaya ; Sara Murphy ; Luigi Marchionni ; Christine L. Hann ; Charles M. RudinSource :
- Molecular cancer [ 1476-4598 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Apoptose (), Autophagie, Bécline-1, Carcinome pulmonaire à petites cellules (anatomopathologie), Carcinome pulmonaire à petites cellules (métabolisme), Carcinome pulmonaire à petites cellules (traitement médicamenteux), Cellules cancéreuses en culture, Charge tumorale (), Chloroquine (administration et posologie), Dérivés du biphényle (administration et posologie), Femelle, Humains, Nitrophénols (administration et posologie), Petit ARN interférent (génétique), Pipérazines (administration et posologie), Prolifération cellulaire (), Protocoles de polychimiothérapie antinéoplasique (pharmacologie), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Protéines membranaires (génétique), Protéines membranaires (métabolisme), Protéines régulatrices de l'apoptose (génétique), Protéines régulatrices de l'apoptose (métabolisme), Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Sulfonamides (administration et posologie), Survie cellulaire, Techniques de knock-down de gènes, Tests d'activité antitumorale sur modèle de xénogreffe, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (métabolisme), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- administration et posologie : Chloroquine, Dérivés du biphényle, Nitrophénols, Pipérazines, Sulfonamides.
- anatomopathologie : Carcinome pulmonaire à petites cellules, Tumeurs du poumon.
- génétique : Petit ARN interférent, Protéines membranaires, Protéines régulatrices de l'apoptose.
- métabolisme : Carcinome pulmonaire à petites cellules, Protéines membranaires, Protéines régulatrices de l'apoptose, Tumeurs du poumon.
- pharmacologie : Protocoles de polychimiothérapie antinéoplasique.
- traitement médicamenteux : Carcinome pulmonaire à petites cellules, Tumeurs du poumon.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Animaux, Apoptose, Autophagie, Bécline-1, Cellules cancéreuses en culture, Charge tumorale, Femelle, Humains, Prolifération cellulaire, Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Survie cellulaire, Techniques de knock-down de gènes, Tests d'activité antitumorale sur modèle de xénogreffe.
English descriptors
- KwdEn :
- Animals, Antineoplastic Combined Chemotherapy Protocols (pharmacology), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Apoptosis (drug effects), Apoptosis Regulatory Proteins (genetics), Apoptosis Regulatory Proteins (metabolism), Autophagy, Beclin-1, Biphenyl Compounds (administration & dosage), Cell Proliferation (drug effects), Cell Survival, Chloroquine (administration & dosage), Drug Resistance, Neoplasm, Female, Gene Knockdown Techniques, Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (metabolism), Lung Neoplasms (pathology), Membrane Proteins (genetics), Membrane Proteins (metabolism), Mice, Mice, Nude, Nitrophenols (administration & dosage), Piperazines (administration & dosage), RNA, Small Interfering (genetics), Small Cell Lung Carcinoma (drug therapy), Small Cell Lung Carcinoma (metabolism), Small Cell Lung Carcinoma (pathology), Sulfonamides (administration & dosage), Tumor Burden (drug effects), Tumor Cells, Cultured, Xenograft Model Antitumor Assays.
- MESH :
- chemical , administration & dosage : Biphenyl Compounds, Chloroquine, Nitrophenols, Piperazines, Sulfonamides.
- chemical , genetics : Apoptosis Regulatory Proteins, Membrane Proteins, RNA, Small Interfering.
- drug effects : Apoptosis, Cell Proliferation, Tumor Burden.
- drug therapy : Lung Neoplasms, Small Cell Lung Carcinoma.
- chemical , metabolism : Apoptosis Regulatory Proteins, Lung Neoplasms, Membrane Proteins, Small Cell Lung Carcinoma.
- pathology : Lung Neoplasms, Small Cell Lung Carcinoma.
- pharmacology : Antineoplastic Combined Chemotherapy Protocols.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Animals, Autophagy, Beclin-1, Cell Survival, Drug Resistance, Neoplasm, Female, Gene Knockdown Techniques, Humans, Mice, Mice, Nude, Tumor Cells, Cultured, Xenograft Model Antitumor Assays.
Abstract
New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies.
DOI: 10.1186/1476-4598-12-16
PubMed: 23452820
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<author><name sortKey="Zinn, Rebekah L" sort="Zinn, Rebekah L" uniqKey="Zinn R" first="Rebekah L" last="Zinn">Rebekah L. Zinn</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Gardner, Eric E" sort="Gardner, Eric E" uniqKey="Gardner E" first="Eric E" last="Gardner">Eric E. Gardner</name>
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<author><name sortKey="Dobromilskaya, Irina" sort="Dobromilskaya, Irina" uniqKey="Dobromilskaya I" first="Irina" last="Dobromilskaya">Irina Dobromilskaya</name>
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<author><name sortKey="Murphy, Sara" sort="Murphy, Sara" uniqKey="Murphy S" first="Sara" last="Murphy">Sara Murphy</name>
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<author><name sortKey="Marchionni, Luigi" sort="Marchionni, Luigi" uniqKey="Marchionni L" first="Luigi" last="Marchionni">Luigi Marchionni</name>
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<author><name sortKey="Hann, Christine L" sort="Hann, Christine L" uniqKey="Hann C" first="Christine L" last="Hann">Christine L. Hann</name>
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<author><name sortKey="Rudin, Charles M" sort="Rudin, Charles M" uniqKey="Rudin C" first="Charles M" last="Rudin">Charles M. Rudin</name>
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<series><title level="j">Molecular cancer</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antineoplastic Combined Chemotherapy Protocols (pharmacology)</term>
<term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term>
<term>Apoptosis (drug effects)</term>
<term>Apoptosis Regulatory Proteins (genetics)</term>
<term>Apoptosis Regulatory Proteins (metabolism)</term>
<term>Autophagy</term>
<term>Beclin-1</term>
<term>Biphenyl Compounds (administration & dosage)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Cell Survival</term>
<term>Chloroquine (administration & dosage)</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Gene Knockdown Techniques</term>
<term>Humans</term>
<term>Lung Neoplasms (drug therapy)</term>
<term>Lung Neoplasms (metabolism)</term>
<term>Lung Neoplasms (pathology)</term>
<term>Membrane Proteins (genetics)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Nitrophenols (administration & dosage)</term>
<term>Piperazines (administration & dosage)</term>
<term>RNA, Small Interfering (genetics)</term>
<term>Small Cell Lung Carcinoma (drug therapy)</term>
<term>Small Cell Lung Carcinoma (metabolism)</term>
<term>Small Cell Lung Carcinoma (pathology)</term>
<term>Sulfonamides (administration & dosage)</term>
<term>Tumor Burden (drug effects)</term>
<term>Tumor Cells, Cultured</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Apoptose ()</term>
<term>Autophagie</term>
<term>Bécline-1</term>
<term>Carcinome pulmonaire à petites cellules (anatomopathologie)</term>
<term>Carcinome pulmonaire à petites cellules (métabolisme)</term>
<term>Carcinome pulmonaire à petites cellules (traitement médicamenteux)</term>
<term>Cellules cancéreuses en culture</term>
<term>Charge tumorale ()</term>
<term>Chloroquine (administration et posologie)</term>
<term>Dérivés du biphényle (administration et posologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Nitrophénols (administration et posologie)</term>
<term>Petit ARN interférent (génétique)</term>
<term>Pipérazines (administration et posologie)</term>
<term>Prolifération cellulaire ()</term>
<term>Protocoles de polychimiothérapie antinéoplasique (pharmacologie)</term>
<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Protéines membranaires (génétique)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Protéines régulatrices de l'apoptose (génétique)</term>
<term>Protéines régulatrices de l'apoptose (métabolisme)</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris</term>
<term>Souris nude</term>
<term>Sulfonamides (administration et posologie)</term>
<term>Survie cellulaire</term>
<term>Techniques de knock-down de gènes</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
<term>Tumeurs du poumon (anatomopathologie)</term>
<term>Tumeurs du poumon (métabolisme)</term>
<term>Tumeurs du poumon (traitement médicamenteux)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Biphenyl Compounds</term>
<term>Chloroquine</term>
<term>Nitrophenols</term>
<term>Piperazines</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
<term>Membrane Proteins</term>
<term>RNA, Small Interfering</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Chloroquine</term>
<term>Dérivés du biphényle</term>
<term>Nitrophénols</term>
<term>Pipérazines</term>
<term>Sulfonamides</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome pulmonaire à petites cellules</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term>
<term>Cell Proliferation</term>
<term>Tumor Burden</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Neoplasms</term>
<term>Small Cell Lung Carcinoma</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Petit ARN interférent</term>
<term>Protéines membranaires</term>
<term>Protéines régulatrices de l'apoptose</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apoptosis Regulatory Proteins</term>
<term>Lung Neoplasms</term>
<term>Membrane Proteins</term>
<term>Small Cell Lung Carcinoma</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carcinome pulmonaire à petites cellules</term>
<term>Protéines membranaires</term>
<term>Protéines régulatrices de l'apoptose</term>
<term>Tumeurs du poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung Neoplasms</term>
<term>Small Cell Lung Carcinoma</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Carcinome pulmonaire à petites cellules</term>
<term>Tumeurs du poumon</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Autophagy</term>
<term>Beclin-1</term>
<term>Cell Survival</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Gene Knockdown Techniques</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Tumor Cells, Cultured</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Apoptose</term>
<term>Autophagie</term>
<term>Bécline-1</term>
<term>Cellules cancéreuses en culture</term>
<term>Charge tumorale</term>
<term>Femelle</term>
<term>Humains</term>
<term>Prolifération cellulaire</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris</term>
<term>Souris nude</term>
<term>Survie cellulaire</term>
<term>Techniques de knock-down de gènes</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
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<front><div type="abstract" xml:lang="en">New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><noCountry><name sortKey="Dobromilskaya, Irina" sort="Dobromilskaya, Irina" uniqKey="Dobromilskaya I" first="Irina" last="Dobromilskaya">Irina Dobromilskaya</name>
<name sortKey="Gardner, Eric E" sort="Gardner, Eric E" uniqKey="Gardner E" first="Eric E" last="Gardner">Eric E. Gardner</name>
<name sortKey="Hann, Christine L" sort="Hann, Christine L" uniqKey="Hann C" first="Christine L" last="Hann">Christine L. Hann</name>
<name sortKey="Marchionni, Luigi" sort="Marchionni, Luigi" uniqKey="Marchionni L" first="Luigi" last="Marchionni">Luigi Marchionni</name>
<name sortKey="Murphy, Sara" sort="Murphy, Sara" uniqKey="Murphy S" first="Sara" last="Murphy">Sara Murphy</name>
<name sortKey="Rudin, Charles M" sort="Rudin, Charles M" uniqKey="Rudin C" first="Charles M" last="Rudin">Charles M. Rudin</name>
</noCountry>
<country name="États-Unis"><region name="Maryland"><name sortKey="Zinn, Rebekah L" sort="Zinn, Rebekah L" uniqKey="Zinn R" first="Rebekah L" last="Zinn">Rebekah L. Zinn</name>
</region>
</country>
</tree>
</affiliations>
</record>
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