Serveur d'exploration Chloroquine

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Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer.

Identifieur interne : 001117 ( Main/Exploration ); précédent : 001116; suivant : 001118

Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer.

Auteurs : Rebekah L. Zinn [États-Unis] ; Eric E. Gardner ; Irina Dobromilskaya ; Sara Murphy ; Luigi Marchionni ; Christine L. Hann ; Charles M. Rudin

Source :

RBID : pubmed:23452820

Descripteurs français

English descriptors

Abstract

New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies.

DOI: 10.1186/1476-4598-12-16
PubMed: 23452820


Affiliations:


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Le document en format XML

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<term>Apoptosis Regulatory Proteins (genetics)</term>
<term>Apoptosis Regulatory Proteins (metabolism)</term>
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<term>Cell Survival</term>
<term>Chloroquine (administration & dosage)</term>
<term>Drug Resistance, Neoplasm</term>
<term>Female</term>
<term>Gene Knockdown Techniques</term>
<term>Humans</term>
<term>Lung Neoplasms (drug therapy)</term>
<term>Lung Neoplasms (metabolism)</term>
<term>Lung Neoplasms (pathology)</term>
<term>Membrane Proteins (genetics)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Mice</term>
<term>Mice, Nude</term>
<term>Nitrophenols (administration & dosage)</term>
<term>Piperazines (administration & dosage)</term>
<term>RNA, Small Interfering (genetics)</term>
<term>Small Cell Lung Carcinoma (drug therapy)</term>
<term>Small Cell Lung Carcinoma (metabolism)</term>
<term>Small Cell Lung Carcinoma (pathology)</term>
<term>Sulfonamides (administration & dosage)</term>
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<term>Apoptose ()</term>
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<term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term>
<term>Protéines membranaires (génétique)</term>
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<term>Protéines régulatrices de l'apoptose (métabolisme)</term>
<term>Résistance aux médicaments antinéoplasiques</term>
<term>Souris</term>
<term>Souris nude</term>
<term>Sulfonamides (administration et posologie)</term>
<term>Survie cellulaire</term>
<term>Techniques de knock-down de gènes</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
<term>Tumeurs du poumon (anatomopathologie)</term>
<term>Tumeurs du poumon (métabolisme)</term>
<term>Tumeurs du poumon (traitement médicamenteux)</term>
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<term>Piperazines</term>
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<term>Chloroquine</term>
<term>Dérivés du biphényle</term>
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<term>Pipérazines</term>
<term>Sulfonamides</term>
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<term>Carcinome pulmonaire à petites cellules</term>
<term>Tumeurs du poumon</term>
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<term>Apoptosis</term>
<term>Cell Proliferation</term>
<term>Tumor Burden</term>
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<term>Small Cell Lung Carcinoma</term>
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<term>Tumeurs du poumon</term>
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<term>Gene Knockdown Techniques</term>
<term>Humans</term>
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<term>Apoptose</term>
<term>Autophagie</term>
<term>Bécline-1</term>
<term>Cellules cancéreuses en culture</term>
<term>Charge tumorale</term>
<term>Femelle</term>
<term>Humains</term>
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<term>Résistance aux médicaments antinéoplasiques</term>
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<term>Souris nude</term>
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<front>
<div type="abstract" xml:lang="en">New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies.</div>
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<name sortKey="Dobromilskaya, Irina" sort="Dobromilskaya, Irina" uniqKey="Dobromilskaya I" first="Irina" last="Dobromilskaya">Irina Dobromilskaya</name>
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<name sortKey="Hann, Christine L" sort="Hann, Christine L" uniqKey="Hann C" first="Christine L" last="Hann">Christine L. Hann</name>
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